LZTS2 and hepatocellular carcinoma: As shown in Fig. 4f, miR-9-5p mimic decreased the luciferase activity in the HCC-1937 and MDA-MB-231 cells which were transfected with LZTS2-3′-UTR-WT (0.36 ± 0.02 vs. 0.99 ± 0.03, 0.35 ± 0.02 vs. 1.02 ± 0.04, both P < 0.001), but not in those transfected with LZTS2-3′-UTR-Mut (1.02 ± 0.03 vs. 1.01 ± 0.04, P = 0.909; 1.02 ± 0.03 vs. 1.01 ± 0.03, P = 0.723).