Interestingly, ‘Myc targets’ was amongst the top up-regulated pathways in tumour ECs in a single-cell analysis of human non-small cell lung cancer (NSCLC).55 Myc has been identified as a driver of the endothelial regeneration process,93 thereby raising the question whether progenitor-like ECs might arise in tumours, and if so, whether they harbour additional heterogeneity in terms of their transcriptome or their response to anti-cancer therapy/AAT. Here, MYC is linked to neoplasm.