BLOC1S3 and Diamond-Blackfan anemia: The data suggests, however, that cellular and animal models of DBA that have generally sought to achieve a 50% reduction in Rp protein expression (Heijnen et al., 2014; Khajuria et al., 2018) could be significantly more severe than occurs in DBA patients, and that actual ribosome subunit concentrations should be measured in DBA patient cells to guide future models.