Notably, knock-out of CReP, one of the two mouse PPP1R15 homologs, causes anemia, similar to DBA (Harding et al., 2009; Da Costa et al., 2018), and PERK-dependent eIF2α phosphorylation occurs in RpL22-deficient mouse αβ T-cells and activates p53 there (Solanki et al., 2016). This evidence concerns the gene EIF2AK3 and anemia (phenotype).