EIF6 and Treacher-Collins syndrome: TAF1B depletion, which also acted through Xrp1 and eIF2α phosphorylation in Drosophila, is a model of Treacher Collins Syndrome (Trainor et al., 2008), and failure to release eIF6, leading to defective LSU maturation and 80 S ribosome formation, causes Schwachman Diamond syndrome (Warren, 2018), two other ribosomopathies where potential contributions of eIF2α phosphorylation are possible.