The opposite effects on M-current of CBD and CB1 agonists like THC fit well with the history of the development of CBD as an antiepileptic drug, which began with anecdotal evidence that extracts from a particular strain of cannabis with high CBD and low THC (‘Charlotte’s Web’) were an effective adjunctive therapy for a child with Dravet syndrome (Maa and Figi, 2014; Rosenberg et al., 2015; Williams and Stephens, 2020). The gene discussed is CNR1; the disease is encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.