PDE10A and Parkinson disease: Interestingly, among these 10 hits we noticed a few proteins of particular importance in DA signaling and have been associated with PD, such as Cacna1e, Darpp-32 [dopamine- and cAMP-regulated neuronal phosphoprotein a.k.a. protein phosphatase 1 regulator inhibitor subunit 1b (Ppp1r1b)], Fgf1, Gng7 (G Protein Subunit Gamma 7), Pde10a (Phosphodiesterase 10A) and SerpinA1a (38–45).