Currently available hormonal therapies for the treatment of uterine fibroids include combined estrogen/progestin oral contraceptives, progestin-only contraceptives (including the progestin-(levonorgestrel-) releasing intrauterine system [LNG-IUS]), and gonadotropin-releasing hormone (GnRH) agonists and antagonists. The gene discussed is GNRH1; the disease is uterine corpus leiomyoma.