Higenamine protects the cardiac injury induced by ischemia/reperfusion, collagen-induced arthritis, and the apoptosis gastric smooth muscle cells in diabetes via the activation of β2-adrenoceptor and phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) signaling pathways [33–35]. The gene discussed is AKT1; the disease is diabetes mellitus.