In order to test whether TDP-43 potentiates neurotoxicity of the AD proteins tau or Aβ, TDP Tg-low animals were crossed with strains expressing wild-type human tau or Aβ1-42 pan-neuronally (tau Tg or Aβ Tg, respectively) to generate the co-expression strains tau+TDP Tg-low and Aβ+TDP Tg-low. Here, MAPT is linked to Alzheimer disease.