The C. elegans tdp-1 gene lacks the C-terminal G-rich domain present in human TDP-43, which is the site of pathological phosphorylation, the location of most ALS-causing mutations in the TARDBP gene, and comprises the fibrillar core of aggregates in FTLD-TDP (De Boer et al., 2020; Arseni et al., 2021). Here, TDP1 is linked to amyotrophic lateral sclerosis.