As controls, we examined whether tau Tg or TDP Tg-low would synergize with a non-AD related neurodegenerative disease model expressing 86 repeats of polyglutamine pan-neuronally (polyQ Tg) (Brignull et al., 2006; Guthrie et al., 2009). The gene discussed is MAPT; the disease is neurodegenerative disease.