Pancreatic cancer is not a RASopathy-associated malignancy; however, zebrafish models of hereditary pancreatic cancer with homozygous truncating mutations in rabl3 displayed stunted growth, craniofacial dysmorphia, abnormal swimming behavior and decreased bone mineralization consistent with a RASopathy-like phenotype (Nissim et al., 2019), raising the possibility that RABL3 is a RASopathy gene. Here, RABL3 is linked to familial pancreatic carcinoma.