The clinical and pathological value of programmed cell death-ligand 1 (PD-L1) expression in the oral squamous cell carcinoma (OSCC) has originated the research of different studies that try to determine the real relationship between this disease and this immune checkpoint since the latest clinical trials have related possible improvements in the blockade of this immune checkpoint through immunotherapy. The gene discussed is CD274; the disease is oral cavity squamous cell carcinoma.