Acidic environment was reported to result in an increase in GRP78, CHOP, caspase12, while the blockade of acid-sensing ion channel 1a (ASIC1a) partially alleviated IDD by the inhabitation of ER stress (Xie et al., 2017; Xie et al., 2018). This evidence concerns the gene HSPA5 and intervertebral disk degenerative disorder.