Interestingly, ERRα is implicated in cholesterol-induced metabolic reprogramming in breast cancer cells through the regulation of OXPHOS genes including NDUFB7, ATP5L, and COX5B in MDA-MB-231, MCF-7, and TNBC-PDX cells (Ghanbari et al., 2021). The gene discussed is ESRRA; the disease is breast cancer.