Furthermore, ERRα, ERRγ, and PGC-1α regulate the enzymes involved in glutamine metabolism in HER2-positive breast cancer cells (McGuirk et al., 2013; Deblois et al., 2016; Vernier et al., 2020b), which is implicated in resistance to the HER2 inhibitor lapatinib (Li et al., 2020; Vernier et al., 2020b). This evidence concerns the gene PPARGC1A and breast carcinoma.