In addition, other isoquinoline alkaloids with AChE inhibitory activity have the potential to act against AD, for instance, palmatine, jatrorrhizine, and coptisine (Ingkaninan et al., 2006; Jung et al., 2009; Hung et al., 2010; Tsai and Lee, 2010; Xiao et al., 2011; Brunhofer et al., 2012; Huang et al., 2012; Mollataghi et al., 2012; Cao et al., 2018; Liu et al., 2019). The gene discussed is ACHE; the disease is Alzheimer disease.