CUR sensitized glioma cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL/ Apo2) resulting in increased apoptosis by arresting hypo-diploid glioma cells in the sub G1 phase, initiating the release of mitochondrial cytochrome -C and cleavage of procaspases-3, 8, 9 (49). This evidence concerns the gene TNFRSF10A and central nervous system cancer.