Activation of PI3K/AKT pathway triggered by growth factor stimulation, oncogenic mutation of PIK3CA (encoding the p110α catalytic subunit of PI3K and/or loss-of-function mutations and deletions in PTEN (a negative regulator of PI3K signaling), is known to coordinate multiple metabolic programs for supporting tumor cell growth and proliferation (112). This evidence concerns the gene PIK3CA and neoplasm.