UCHL1 and brain ischemia: In the rat model of cerebral ischemia, the classical protein kinase C gamma (cPKCγ) alleviated the damage of stroke, possibly by downregulating ubiquitin C-terminal hydrolase L1 (UCHL1), upregulating ERK-mTOR pathway, alleviating autophagy and apoptosis, and finally playing a protective role in the brain injury [45].