WIPI1 and early-onset autosomal dominant Alzheimer disease: A recent study found that the expression of autophagy-related genes ATG1, ATG8a, and ATG18 in Drosophila melanogaster was downregulated with aging, and its subsequent neuronal dysfunction and Alzheimer's disease phenotype were considered to be related to the decrease of autophagy activity and overproduction of Aβ [27].