ADIPOQ and Alzheimer disease: At day 4, patients in the melatonin group had significantly lower fasting blood glucose and HOMA-IR level compared with the placebo group (P=0.003 and P=0.04, respectively) whereas serum adiponectin, insulin and HOMA-AD level did not differ significantly (p>0.2, P=0.16, P=0.15, respectively).