Macroscopic tumor formation was assessed in view of overall tumor area along the SCJ and size of individual tumors at an early stage (9 months) of tumorigenesis (L2-IL1B: n = 8; L2-IL1B.mTERC−/− G2: n = 9) and at a later stage (12 months; L2-IL1B: n = 8; L2-IL1B.mTERC−/− G2: n = 8) and showed significantly stronger tumor coverage in 12-months-old L2-IL1B.mTERC−/− G2 mice compared to 12 month old L2-IL1B mice (Figure 3A and 3B). The gene discussed is IL1B; the disease is neoplasm.