Yeast-induced fever rat models present an excellent platform for understanding entry of exogenous pyrogens into the body, stimulation of immune cells and endogenous pyrogens, such as IL-1β, TNF-α, IL-6, and other thermogenic cytokines that regulate the temperature regulation centers through neuronal mediators, causing fever, blood rheology, and abnormalities of coagulation factors [4, 18]. Here, TNF is linked to Fever.