EDN1 and Fever: Next, we evaluated the effect of XDT and XDT-cs extracts on yeast-induced fever rats with BHSS and glutamate-induced PC12 cells and found that XDT not only significantly downregulated expression of TNF-α, IL-1, NF-κb, COX-2, ICAM-1, MMP-9, ET-1, NO, SOD, and TXB2 but also downregulated phosphorylation of p65 and had a neuroprotective effect.