EP300 and amyotrophic lateral sclerosis: In support of this notion, although both Tip60- and p300-targeted Khib substrates are involved in several pathways such as ribosome (adjusted p = 4.76E − 12), biosynthesis of amino acids (adjusted p = 2.98E − 07), and carbon metabolism (adjusted p = 7.10E − 09), Tip60-mediated Khib substrates are uniquely enriched in protein processing in endoplasmic reticulum (adjusted p = 6.10E − 06), Prion disease (adjusted p = 3.74E − 04), Parkinson disease (adjusted p = 1.16E − 03), and amyotrophic lateral sclerosis (adjusted p = 6.80E − 04) (Figure 4(b)).