For example, proteasome subunit alpha type-1 (PSMA1), 26S proteasome regulatory subunit 7 (PSMC2), 26S proteasome non-ATPase regulatory subunit 7 (PSMD7), 26S proteasome regulatory subunit 8 (PSMC5), and the other six proteasome complex members are involved in three pathways, including proteasome (adjusted p = 1.53E − 05), Parkinson disease (adjusted p = 1.16E − 03), Prion disease (adjusted p = 3.74E − 04), and amyotrophic lateral sclerosis (adjusted p = 6.80E − 04) (Figure 3(b)). This evidence concerns the gene PSMC5 and prion disease.