Activated PXR inhibits apoptosis in colon cancer cells (HCT116 and colon LS180) through overexpression of antiapoptotic genes, such as BAG3, BIRC2, and MCL-1, as well as suppression of apoptosis, inducing genes, such as BAK1 and TP53 [112]. Here, NR1I2 is linked to malignant colon neoplasm.