In contrast, the Cg1, PrL, IL, CA1, CA3, and DG were downregulated in the c-Fos expression after the cue manipulations in fear behavior, indicating the Cg1, PrL, IL, CA1, CA3, and DG contributed to a cue-induced fear reduction in PTSD. The gene discussed is PRL; the disease is post-traumatic stress disorder.