The c-Fos expression data showed that the Cg1, IL, and NAc upregulated the c-Fos expression in fear behavior; however, the BLA downregulated the c-Fos expression in fear behavior for PTSD symptoms through the EE manipulations, indicating the Cg1, IL, NAc, and BLA controlled the EE-induced fear reduction. The gene discussed is FOS; the disease is post-traumatic stress disorder.