CD4 and Shock: It should be noted that in their SD rat models of traumatic hemorrhagic shock, Masoumi et al. [18] discovered that HES resuscitation regulates the balance of TH1/TH2 response, inhibits NF-κB activation, and promotes CD4+T cell apoptosis of the traumatic hemorrhagic rats, thus improving the immunosuppression, disorder, and inflammation of the rats, which is also in line with our results.