Li et al. reported that the combined treatment of acupuncture and Shenqi Yigan decoction elevated the proportion of CD3+, CD4+ T lymphocyte subsets, and CD4+/CD8+ ratio in peripheral blood, whereas it decreased the proportion of CD8+, thereby improving the hepatic function of patients with HBV-induced liver fibrosis and reducing the inflammatory reaction [28]. Here, CD4 is linked to Hepatic fibrosis.