We confirmed that both baicalein and wogonin can inhibit the proliferation of NPC CNE2 and 5-8F cells and induce apoptosis by CCK8 and Annexin V-FITC/PI double fluorescence staining, which is consistent with the results of network pharmacological prediction, indicating that the method based on network pharmacology to predict the effective components of TCM is scientific and feasible. This evidence concerns the gene ANXA5 and nasopharyngeal carcinoma.