Other hypothesized factors for immune resistance include tumor exploitation of the PD-1/PD-L axis, immuno-editing in tumor cells, the immunosuppressive effects of long non-coding RNAs (lncRNAs), and insufficient re-invigoration of exhausted CD8+ T cells (Drake et al., 2006) (Sun et al., 2020). This evidence concerns the gene CD8A and neoplasm.