In addition to CCL20, the expression of multiple chemokines (CCL17, CCL27, CXCL9, CXCL10, CXCL11) and chemokine receptors (CCR4, CXCR3) were also repressed in K17 KO mice upon treatment with OXA and K17-siRNA-transfected HaCaT cells, suggesting that other chemokines related to K17 may also participate in the development of ACD through specific signaling pathways like as CCL20. The gene discussed is CXCR3; the disease is granular corneal dystrophy type II.