The 14 pathways were pentose phosphate pathway, arginine and proline metabolism, phospholipase D signaling pathway, C-type lectin receptor signaling pathway, IL-17 signaling pathway, oxytocin signaling pathway, regulation of lipolysis in adipocytes, renin secretion, AGE-RAGE signaling pathway in diabetic complications, Leishmaniasis, human cytomegalovirus infection, human papillomavirus infection, bladder cancer and rheumatoid arthritis. The gene discussed is REN; the disease is leishmaniasis.