TIMP1 and systemic sclerosis: Serum PIIINP, TIMP-1, and ELF score were significantly higher in patients with SSc than in healthy controls [PIIINP: 10.31 (7.83–14.10) vs. 5.61 (4.69–6.30), p < .001; TIMP-1: 110.73 (66.21–192.45) vs. 61.81 (48.86–85.24), p < .001; ELF: 10.34 (9.91–10.86) vs. 9.68 (9.38–9.99), p < .001], while no statistically significant difference was observed in serum HA between SSc patients and healthy controls [192.00 (124.17–265.07) vs. 168.16 (132.57–219.11) p = .206; Figures 1A–D].