In this study, we revealed that depletion of wt-p53 in prostate cancer cells favored early steps of bone metastatic homing and colonization, conferring chemotaxis and attachment of prostate cancer cells to osteoblasts, through increasing the activity of the CXCR4/CXCL12 chemokine axis. The gene discussed is CXCR4; the disease is Familial prostate cancer.