We observed that TP53-KO cells had a faster migration rate than the control tumor cells, whereas TP53 overexpression showed the opposite effect (Figures 2A,B, left upper panel); the pro-migration function of TP53 depletion on prostate cancer cells was more remarkable when stimulated by osteoblast conditioned medium (Figure 2A). Here, TP53 is linked to Familial prostate cancer.