SOD1 and hepatocellular carcinoma: In addition and in agreement with previous observations in HCC model, the livers of HCC rats in this study showed that the depletion of endogenous antioxidants such as SOD and CAT were responsible for reversing the ROS-induced oxidative damage (Marra et al., 2011; Hamza et al., 2018; Hamza et al., 2021).