SGCG and ischemia: Similarly, the T-type channel enhancer SAK3 prevented cognitive impairment in different disease states and models such as hypothyroidism, ischemia, and AD models (Yabuki et al., 2017; Husain et al., 2018; Yuan et al., 2021) and showed beneficial effects in an animal model of intellectual disability syndrome (Dhanalakshmi et al., 2021).