TRPV1 and hypertensive disorder: However, using an in vivo rodent hypertension model, the transient receptor potential vanilloid 1 (TRPV1) channel was proven to be involved in RGC apoptosis induced by long pressure stress (+70 mmHg for 48 h), likely through the inflow of extracellular Ca2+ (Sappington et al., 2009).