At the clinical level, these results suggest not only a role for MFN2 in these MCSs but also the participation of these contacts in the pathophysiology of Charcot-Marie-Tooth (CMT) neuropathy caused by mutations in MFN2. GDAP1 and MFN2 share some features: they are located in the OMM and participate in mitochondrial dynamics (MFN2, fusion; GDAP1, fission); regulate mitochondria-ER contacts at MAMs and both genes are linked to axonal CMT with similar clinical features. Here, MFN2 is linked to Charcot-Marie-Tooth disease.