We have previously demonstrated that IL-36R is expressed predominantly by sub-mucosal lamina propria cells in the colons of IBD patients.15 Furthermore, we and others have previously demonstrated that IL-36 cytokines can play an important role in modulating mucosal T cell responses in murine models of colitis.15,18 Therefore, we investigated the potential of T cells to respond to IL-36 cytokines in the inflamed intestinal biopsies from IBD patients. Here, IL1RL2 is linked to inflammatory bowel disease.