RET and neoplasm: As mechanical induction of hyperproliferation and tumorigenesis by tumor growth pressure is correlated with the activation of the mechanosensitive Ret kinase in vivo8, here we thus tested whether the later process could be due to an abnormal over-activation of the Ret mechanosensitive pathway, and of the number of SC downstream, by pathological permanent tumor growth pressure mechanical stresses, added to the endogenous pulsed physiological pulsatile stresses.