The inhibition of Lgr5 expression induction in response to ex-vivo direct 1kPa mechanical stimulation59 in the presence of Danu, like in the presence of Vande (Supplementary Fig. 18c, d) confirms the specific role of Ret in the β-cat dependent mechanical indution of the Lgr5 positive SC at the orgin of ACF formation in response to magnetically-mimicked tumor growth pressure in vivo. Here, LGR5 is linked to neoplasm.