Indeed, we found the magnetically-mimicked permanent tumor growth pressure as Ret-mechanical-activation-dependent inducer of a pathological 1.5-fold increase in the number of SC and PC into mice crypts, leading to a pathological level of SC per crypt in the Apc heterozygous context representative of 85% of human colon tumors, with levels nearly twice higher than in uncompressed WT. The gene discussed is APC; the disease is neoplasm.