Indeed, we furthermore find that the effect of high-frequency pulsatile stresses on the stimulation of physiological SC rate is pathologically over-amplified by additional permanent anomalous tumor growth pressure, leading to a doubling of SC and proliferative cell (PC) number, as well as to the generation of CSC markers expression in Apc mutated mice (a mutation found in 85% of human somatic colon tumors30,31), and to tumorigenic hyperproliferation mechanical stimulation. This evidence concerns the gene APC and neoplasm.