RET and colon adenocarcinoma: As this tumor growth pressure should increase with tumor stage and partially decrease after the leaking of the primary tumor at the invasive stage, we actually observed the increased Ret activation with the tumor progression grade from 0 in the WT tissue to 3 in the early invasive intra-mucosal adenocarcinomas, and a 1.5-score lower activation in colon adenocarcinomas infiltrating the submucosa, the muscularis and/or the subserosa (Fig. 7b).