TCGA data reveals that NNMT mRNA expression is positively correlated with INMT but not with PNMT. Based on STRING interaction network analysis, NNMT interacts with ADK, APP, ATF6, BMF, BRD4, CDC37, or CRYZ; however, our analysis of TCGA colorectal cancer cohorts found no correlation between NNMT and these entities at mRNA expression level. This evidence concerns the gene CRYZ and colorectal cancer.