It is interesting that we observed Aβ deposits in the olfactory nerve earlier than in the bulb, as one study in an Alzheimer’s disease mouse model (APP/PS1 mice) showed that the terminal end of the olfactory nerve within the nasal olfactory epithelium is the first nervous system area to exhibit Aβ deposition, which then progresses to the olfactory bulb and other CNS areas72. The gene discussed is APP; the disease is early-onset autosomal dominant Alzheimer disease.