APP and early-onset autosomal dominant Alzheimer disease: In a transgenic mouse model of familial Alzheimer’s disease (5xFAD mice, which exhibit the human amyloid precursor protein and presenilin 1 transgenes with five mutations linked to Alzheimer’s disease), intracranial injection with Salmonella typhimurium resulted in a dramatic increase in Aβ deposition after only 48 h13.