TGFB1 and chronic kidney disease: Kaplan–Meier survival analyses showed that the elderly, normal high value of urea nitrogen, normal high value of TGF-β, normal high value of ADMA, and diabetes (we defined age ≥ 60 years as the elderly, taking the higher quartile of other measurement data as their normal high values) were significantly associated with chronic kidney disease onset in our cohort (Fig. 2).