ESR1 and neoplasm: Across the entire cohort, high LAT1 expression was significantly correlated with estrogen receptor (ER) negativity (p < 0.0001), progesterone receptor (PgR) negativity (p < 0.0001), human epidermal growth factor receptor 2 (HER2) positivity (p < 0.0001), large tumor size (p = 0.016), and high histological grade (p < 0.0001) (Table 1).