Confirmatory analysis comparing between areas only of significantly reduced participation between DLB and controls found significantly higher mean expression of ADRA2A (alpha-2a adrenergic receptor; P = 0.003, independent samples t test) and CHRM2 (muscarinic acetylcholine receptor M2; P = 0.008) compared to all other regions that were not significantly different, suggesting that regions that were segregated may have been so due to insufficient recruitment of activity within these receptor distributions. The gene discussed is CHRM2; the disease is Lewy body dementia.