Consistent with all other mouse HCC models described above, Ehd2-KO (Ehd2−/−) mice had smaller tumors with a weaker macropinocytic capability with the fibrotic background than Ehd2-wild-type (WT) mice (Ehd2+/+) (Fig. 7e and Supplementary Fig. 17e). This evidence concerns the gene EHD2 and hepatocellular carcinoma.