EHD2 and hepatocellular carcinoma: Similar to somatic KO of Ehd2, germline KO of Ehd2 repressed the growth and macropinocytosis of Tp53KO; c-MycOE HCC and Keap1KO; c-MycOE HCC, which were induced by HDTVi (Fig. 7c, d and Supplementary Fig. 17a, c).