We found that myeloid cells from two clusters (aMΦ, bMΦ, Supplementary Fig. 5), characterized by the expression of tumor-associated macrophage genes (CD163, CCL4, APOE, and HLA-DRA) were strongly connected to the CD8+ exhausted and CD4+ Th1 T cell clusters. This evidence concerns the gene HLA-DRA and neoplasm.