Given the lack of single-cell resolution in the stRNA-seq, the dataset was supplemented with imaging mass cytometry (IMC, n = 1) to determine precise cellular distances between the CD8+ T cell population (PD1+/TIM3+/CD8A+) and the tumor subgroups (MES-like: EGFR+, CHI3L1+; AC-like: EGFR+, HOPX+; NPC-like: EGFR+, CD24+; OPC-like: EGFR+, OLIG1+), Fig. 4h. Here, CHI3L1 is linked to neoplasm.