The profile for cancer-associated gene mutations also showed a group-specific segregation pattern (PIK3CA [p. E453K] in the first group, PTEN [p. Y188 X] and PIK3R1 [p. R574del] in the second group, and KRAS [p. G12V] in G13) (Fig. 7f). Here, PIK3R1 is linked to cancer.