Given the severe phenotype caused by ablation of MRM2 in cultured cells, as well as reports of patients harbouring variants in the coding gene presenting with a Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like episodes (MELAS)-like pathology13, we investigated the relevance of this protein for whole-organism and tissue-specific homeostasis in a Drosophila melanogaster model. This evidence concerns the gene MRM2 and MELAS.