Antibody arrays covering a large spectrum of cytokines, chemokines and growth factors, showed that TRPC3 downregulation is associated with a pro-inflammatory and pro-tumour SASP, notably including IL-8, ENA-78, GRO-alpha and other soluble factors associated with tumour progression and aggressiveness (Fig. 8a and Supplementary Fig. 8a). Here, CXCL5 is linked to neoplasm.