Moreover, in the tumours expressing low levels of TRPC3, the gene set enrichment analysis (GSEA) conducted on the data from the gene expression omnibus (GEO) dataset GSE35988 from prostate cancer tissues showed a strong enrichment of the genes upregulated in senescence (Human Cellular Senescence Gene Database, HCSGD35, Supplementary Fig. 1m). This evidence concerns the gene TRPC3 and Familial prostate cancer.