HIF1A and postmenopausal osteoporosis: However, a correlation between RANKL and HIF1A gene expression was not detectable in this dataset, likely because of the low sample numbers, sampling limitations, and low stability of HIF1A in the peripheral microenvironment.51,52 Therefore, further studies on local bone marrow B cells from postmenopausal patients will be urgently needed to understand the role of B cell-specific HIF-1α signaling in postmenopausal osteoporosis.