Consistent with loss of mitochondrial integrity, Mic60-low tumor cells activated quality-control mechanisms of autophagy with punctate GFP-LC3 staining (SI Appendix, Fig. S3E), processing of LC3 to a lipidated form, and upregulation of p62, i.e., sequestosome (SI Appendix, Fig. S3F). This evidence concerns the gene MAP1LC3A and neoplasm.