Furthermore, the combination of a checkpoint inhibitor (PD-L1 antibody) with PG@KMCM is explored to check whether the tumor microenvironment can be reshaped by means of elimination of PD-L1-positive macrophages and down-regulation of PD-L1 to improve the therapeutic benefits of PG@KMCM for the pancreatic tumor treatment. The gene discussed is CD274; the disease is pancreatic neoplasm.