ERBB2 and metastatic malignant neoplasm in the lymph nodes: However, in the multivariate analysis, TIL density was not an significant independent factor for DFS (P = 0.227, HR = 0.699) and since skin invasion (P = 0.012, HR = 2.180), lymph node metastasis (P = 0.001, HR = 2.918), HER2-positive (P = 0.020, HR = 0.498), responders in ORR (P < 0.001, HR = 0.247), and pCR (P < 0.001, HR = 0.315) influenced the DFS.